CART Peptide Regulates Psychostimulant-Induced Activity and Exhibits a Rate Dependency
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چکیده
منابع مشابه
CART Peptide Regulates Psychostimulant-Induced Activity and Exhibits a Rate Dependency.
Since the identification of CART peptides in the 1990s [1], evidence has been steadily accumulating that they are involved in a great variety of physiologic processes. These include feeding and body weight, depression and anxiety, stress, hormonal control, psychostimulant (PS) action [2,3,4,5,6,7,8], and others. With regard to PS action, CART peptides appear to regulate the action of cocaine, a...
متن کاملIntraperitoneal Administration of CART 55-102 Inhibits Psychostimulant-Induced Locomotion.
CART (cocaine and amphetamine regulated transcript) peptide functions as both a neurotransmitter and a hormone and is found both in the central nervous system (CNS) and in the periphery. CART peptide in the nucleus accumbens (NAc) has been implicated in the regulation of cocaine-dopamine-mediated locomotion and self-administration, and amphetamine-mediated locomotion and behavior. However, ther...
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Evidence suggests that CART (cocaine-amphetamine regulated transcript) peptides are mediators or modulators of the actions of psychostimulant drugs. In this study, the effects of intra-accumbal injections of rat long form (rl) CART 55-102 were examined. Injection of the peptide alone had no effect, but pretreatment with the peptide blunted or reduced the locomotor-inducing effects of cocaine af...
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CART peptide induces neuroregeneration in stroke rats
Utilizing a classic stroke model in rodents, middle cerebral artery occlusion (MCAo), we describe a novel neuroregenerative approach using the repeated intranasal administration of cocaine- and amphetamine-regulated transcript (CART) peptide starting from day 3 poststroke for enhancing the functional recovery of injured brain. Adult rats were separated into two groups with similar infarction si...
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ژورنال
عنوان ژورنال: Journal of Drug and Alcohol Research
سال: 2017
ISSN: 2090-8334,2090-8342
DOI: 10.4303/jdar/236032